Amino Acid Treatment (CAAT)—A Novel Nutritional Approach to Cancer
By Michael B. Schachter, MD, CNS, FACAM
Angelo P. John, a cancer
theorist for more than 40 years, has developed an extremely interesting
and promising nutritional approach to help cancer patients.
The treatment is called Controlled Amino Acid Treatment or CAAT. CAAT is an amino acid and carbohydrate
deprivation protocol using scientifically formulated amino acids. It is based on the fact that the needs of normal cells and cancer
cells are quite different. By
manipulating the diet of a cancer patient and supplying a proprietary
blend of amino acids (the building blocks of protein in the body), cancer
cells may be literally starved to death. The program consists of: (1) a
strict diet; (2) a special amino acid blend, which contains high doses of
certain amino acids and low doses of others—the exact blend depends to
some extent on the type of cancer being treated; (3) certain nutritional
supplements and the avoidance of others.
The treatment attacks cancer cells in four ways: (1) It helps to
prevent new blood vessel formation, which is necessary for the growth of
solid cancers; (2) It interferes with the cancer cells ability to produce
energy by blocking a process called glycolysis in cancer cells; (3) It
reduces the ability of the body to produce growth factors that stimulate
cancers to grow; and (4) It interferes with the production of specific
amino acids that are necessary for DNA replication in cancer cells.
The diet is quite strict and is low in both carbohydrates and
protein. Fat intake is
moderate and involves specific fats. The amino acid blend reduces certain amino acids (such as glycine,
valine, leucine and isoleucine) and increases others, resulting in reduced
production of the protein elastin, which is necessary for new blood vessel
contrast to normal cells, which produce energy primarily through the use
of oxygen, cancer cells produce energy by a process known as glycolysis
because their mitochondria (energy producing structures in cells that
utilize oxygen) are damaged and not capable of utilizing oxygen the way
normal cells do. The strict diet and amino acid blend attack the
glycolysis process in cancer cells, thus helping to prevent the production
of energy in cancer cells.
growth factors produced in the body, such as human growth hormone and
insulin growth factor 1 (IGF1) tend to stimulate cancer growth. This
program with its reduced calorie and protein diet tends to reduce the
production of these growth factors.
growth of cancer cells requires certain amino acids (like glycine) and
nutrients (like vitamin B6) for replication of the cancer cells’ DNA. The reduction of these nutrients in this CAAT protocol helps to
inhibit DNA replication in cancer cells.
number of nutritional supplements are recommended in this program. These
may include, but are not limited to: (1) vitamins A, C and D; (2)
D-Limonene; (3) N-Acetylcysteine (NAC); (4) Grape Seed Extract; (5)
Lycopene; and others. On the other hand, most of the B vitamins and
especially vitamin B6 need to be avoided because they enhance the
glycolysis process or DNA replication.
program has been used since 1994 in very advanced cancer patients either
combined with conventional treatment of radiation and/or chemotherapy or
without these conventional treatments. Angelo John develops these
nutritional programs for cancer patients with the cooperation of the
patient’s oncologist or with nutritionally oriented complementary and
alternative physicians who work with cancer patients. The results so far have been quite remarkable. For more detailed
information on this program, check out A.P. John's website: http://www.apjohncancerinstitute.org.
The Schachter Center is collaborating with Mr. John in the management of
several cancer patients.
Regardless of the type of cancer one has,
cancer cells all survive through the same biochemical processes. CAAT
interferes with these processes and causes the cancer cells to die,
significantly increasing the chances of recovery. However, because each
patient is unique, CAAT is designed for one's specific needs, taking into
account the person's patient profile and medical history. A personalized
amino acid deprivation formula and food plan is designed for each
patient's individual requirements.